|
J "Neurosci Behav Physiol". 1993, Jul-Aug; 23(4):344-51.
The neuropharmacological restoration of cognitive functions of cats following a lesion to the basal nuclei of the forebrain (Meynert's nucleus).
Mukhin E.I., Nabieva T.N., Mukhina Yu.K.
Brain Institute of Russian Academy of Medical Sciences, 105064, per. Obukha 5, Moscow, Russia.
The functions of generalization and abstraction in an experimental model of Alzheimer's disease (the lesion of Meynert's nuclei in cats) were studied against the background of stimulation and inhibition of the cholinergic, GABAergic, and dopaminergic systems of the brain. It was demonstrated that the cholinergic system is a key system for the formation of the function of generalization, the dopaminergic system improves simple forms of learning, while the GABAergic system is actively involved in the establishment of complex types of associations.
|